Peres MA, Macpherson LMD, Weyant RJ, Daly B, Venturelli R, Mathur MR, et al. Oral diseases: a global public health challenge. Lancet. 2019;394:249–60.
Google Scholar
Wolf TG, Cagetti MG, Fisher JM, Seeberger GK, Campus G. Non-communicable diseases and oral health: an overview. Front Oral Health. 2021;2:725460.
Google Scholar
Petropoulou P, Kalemikerakis I, Dokoutsidou E, Evangelou E, Konstantinidis T, Govina O. Oral health education in patients with diabetes: a systematic review. Healthcare. 2024;12:898.
Google Scholar
Lu L, Zhao D, Li C, Sun Y, Geng F, Zhang S, et al. The role of periodontitis in the development of atherosclerotic cardiovascular disease in participants with the components of metabolic syndrome: a systematic review and meta-analysis. Clin Oral Investig. 2024;28:339.
Google Scholar
Bechina C, Pockpa AD, Amador Del Valle G, Soueidan A, Lamirault G, Struillou X. Effects of periodontal therapy on cardiovascular risk biomarkers: a systematic review. Oral Health Prev Dent. 2025;23:457–67.
Google Scholar
Garcia-Martos JM, Valverde-Bolivar FJ, Campillo-Lopez MT, Delgado-Rodriguez M. Association between periodontal disease and gestational diabetes: systematic review and meta-analysis. Prim Care Diab. 2025;19:1–6.
Google Scholar
Kazeminia M, Abdi A, Shohaimi S, Jalali R, Vaisi-Raygani A, Salari N, et al. Dental caries in primary and permanent teeth in children’s worldwide, 1995 to 2019: a systematic review and meta-analysis. Head Face Med. 2020;16:22.
Google Scholar
Jackson SL, Vann WF Jr, Kotch JB, Pahel BT, Lee JY. Impact of poor oral health on children’s school attendance and performance. Am J Public Health. 2011;101:1900–6.
Google Scholar
Sheiham A. Dental caries affects body weight, growth and quality of life in pre-school children. Br Dent J. 2006;201:625–6.
Google Scholar
Giacaman RA, Fernandez CE, Munoz-Sandoval C, Leon S, Garcia-Manriquez N, Echeverria C, et al. Understanding dental caries as a non-communicable and behavioral disease: management implications. Front Oral Health. 2022;3:764479.
Google Scholar
Orlova E, Dudding T, Chernus JM, Alotaibi RN, Haworth S, Crout RJ, et al. Association of early childhood caries with bitter taste receptors: a meta-analysis of genome-wide association studies and transcriptome-wide association study. Genes. 2022;14:59.
Google Scholar
Kulshrestha A, Shah P, Chaudhary S, Lakade L, Jajoo SS, Patil K. Assessment of Correlation of salivary factors with genetic taste perception in preschool children with and without early childhood caries: an in vivo study. Int J Clin Pediatr Dent. 2025;18:293–8.
Google Scholar
Dong H, Liu J, Zhu J, Zhou Z, Tizzano M, Peng X, et al. Oral microbiota-host interaction mediated by taste receptors. Front Cell Infect Microbiol. 2022;12:802504.
Google Scholar
Medapati MR, Singh N, Bhagirath AY, Duan K, Triggs-Raine B, Batista EL Jr, et al. Bitter taste receptor T2R14 detects quorum sensing molecules from cariogenic Streptococcus mutans and mediates innate immune responses in gingival epithelial cells. FASEB J. 2021;35:e21375.
Google Scholar
Schwartz M, Canon F, Feron G, Neiers F, Gamero A. Impact of oral microbiota on flavor perception: from food processing to in-mouth metabolization. Foods. 2021;10:2006.
Google Scholar
van Stokkom VL, Blok AE, van Kooten O, de Graaf C, Stieger M. The role of smell, taste, flavour and texture cues in the identification of vegetables. Appetite. 2018;121:69–76.
Google Scholar
Cornwell TB, McAlister AR. Alternative thinking about starting points of obesity. Development of child taste preferences. Appetite. 2011;56:428–39.
Google Scholar
Werthmann J, Jansen A, Havermans R, Nederkoorn C, Kremers S, Roefs A. Bits and pieces. Food texture influences food acceptance in young children. Appetite. 2015;84:181–7.
Google Scholar
Harari D, Redlich M, Miri S, Hamud T, Gross M. The effect of mouth breathing versus nasal breathing on dentofacial and craniofacial development in orthodontic patients. Laryngoscope. 2010;120:2089–93.
Google Scholar
Ballikaya E, Guciz Dogan B, Onay O, Uzamis Tekcicek M. Oral health status of children with mouth breathing due to adenotonsillar hypertrophy. Int J Pediatr Otorhinolaryngol. 2018;113:11–15.
Google Scholar
Guilleminault C, Sullivan SS, Huang YS. Sleep-disordered breathing, orofacial growth, and prevention of obstructive sleep apnea. Sleep Med Clin. 2019;14:13–20.
Google Scholar
Watt RG, Daly B, Allison P, Macpherson LMD, Venturelli R, Listl S, et al. Ending the neglect of global oral health: time for radical action. Lancet. 2019;394:261–72.
Google Scholar
Ravaghi V, Rezaee A, Pallan M, Morris AJ. Childhood obesity and dental caries: an ecological investigation of the shape and moderators of the association. BMC Oral Health. 2020;20:338.
Google Scholar
Mennella JA, Reiter A, Brewer B, Pohlig RT, Stallings VA, Trabulsi JC. Early weight gain forecasts accelerated eruption of deciduous teeth and later overweight status during the first year. J Pediatr. 2020;225:174–81.e2.
Google Scholar
Craig SJC, Blankenberg D, Parodi ACL, Paul IM, Birch LL, Savage JS, et al. Child weight gain trajectories linked to oral microbiota composition. Sci Rep. 2018;8:14030.
Google Scholar
Elfrink ME, Veerkamp JS, Aartman IH, Moll HA, Ten Cate JM. Validity of scoring caries and primary molar hypomineralization (DMH) on intraoral photographs. Eur Arch Paediatr Dent. 2009;10:5–10.
Google Scholar
Barman M, Murray F, Bernardi AI, Broberg K, Bölte S, Hesselmar B, et al. Nutritional impact on immunological maturation during childhood in relation to the environment (NICE): a prospective birth cohort in northern Sweden. BMJ Open. 2018;8:e022013.
Google Scholar
Agranyoni O, Rowley T, Johnson SB, Volk H, Schleif W, Hernandez RG, et al. Oral microbiome composition is associated with depressive symptoms during pregnancy. Brain Behav Immun Health. 2025;45:100978.
Google Scholar
Brandstetter S, Toncheva AA, Niggel J, Wolff C, Gran S, Seelbach-Göbel B, et al. KUNO-Kids birth cohort study: rationale, design, and cohort description. Mol Cell Pediatr. 2019;6:1.
Google Scholar
Quigley GA, Hein JW. Comparative cleansing efficiency of manual and power brushing. J Am Dent Assoc. 1962;65:26–29.
Google Scholar
Turesky S, Gilmore ND, Glickman I. Reduced plaque formation by the chloromethyl analogue of vitamin C. J Periodontol. 1970;41:41–43.
Google Scholar
Greene JC, Vermillion JR. The simplified oral hygiene index. J Am Dent Assoc. 1964;68:7–13.
Google Scholar
World Health Organization. Oral health surveys: basic methods 5th ed. 2013.
Ismail AI, Sohn W, Tellez M, Amaya A, Sen A, Hasson H, et al. The international caries detection and assessment system (ICDAS): an integrated system for measuring dental caries. Community Dent Oral Epidemiol. 2007;35:170–8.
Google Scholar
Monse B, Heinrich-Weltzien R, Benzian H, Holmgren C, van Palenstein Helderman W. PUFA-an index of clinical consequences of untreated dental caries. Community Dent Oral Epidemiol. 2010;38:77–82.
Google Scholar
Soh HJ, Rowe K, Davey MJ, Horne RSC, Nixon GM. The OSA-5: development and validation of a brief questionnaire screening tool for obstructive sleep apnea in children. Int J Pediatr Otorhinolaryngol. 2018;113:62–66.
Google Scholar
National Center for Biotechnology Information. PubChem Compound Summary for CID 697057, 6-Phenyl-2-thiouracil. Retrieved September 2, 2025 from https://pubchem.ncbi.nlm.nih.gov/compound/6-Phenyl-2-thiouracil.
Schwartz C, Chabanet C, Szleper E, Feyen V, Issanchou S, Nicklaus S. Infant acceptance of primary tastes and fat emulsion: developmental changes and links with maternal and infant characteristics. Chem Senses. 2017;42:593–603.
Google Scholar
Schwartz C, Issanchou S, Nicklaus S. Developmental changes in the acceptance of the five basic tastes in the first year of life. Br J Nutr. 2009;102:1375–85.
Google Scholar
Steiner JE. Human facial expressions in response to taste and smell stimulation. Adv Child Dev Behav. 1979;13:257–95.
Google Scholar
Rotstein M, Stolar O, Uliel S, Mandel D, Mani A, Dollberg S, et al. Facial expression in response to smell and taste stimuli in small and appropriate for gestational age newborns. J Child Neurol. 2015;30:1466–71.
Google Scholar
Greimel E, Macht M, Krumhuber E, Ellgring H. Facial and affective reactions to tastes and their modulation by sadness and joy. Physiol Behav. 2006;30:261–9.
Google Scholar
Bredie WLP, Tan HSG, Wendin K. A comparative study on facially expressed emotions in response to basic tastes. Chemosens Percept. 2014;7:1–9.
Google Scholar
Agerholm DM, Ashley FP. Clinical assessment of periodontitis in young adults-evaluation of probing depth and partial recording methods. Community Dent Oral Epidemiol. 1996;24:56–61.
Google Scholar
DeDonno MA. Dental anxiety, dental visits and oral hygiene practices. Oral Health Prev Dent. 2012;10:129–33.
Google Scholar
Stouthard ME, Hoogstraten J. Prevalence of dental anxiety in the Netherlands. Community Dent Oral Epidemiol. 1990;18:139–42.
Google Scholar
Hariyani N, Do LG, Spencer AJ, Thomson WM, Scott JA, Ha DH. Maternal caries experience influences offspring’s early childhood caries-a birth cohort study. Community Dent Oral Epidemiol. 2020;48:561–9.
Google Scholar
Kahharova D, Pappalardo VY, Buijs MJ, de Menezes RX, Peters M, Jackson R, et al. Microbial indicators of dental health, dysbiosis, and early childhood caries. J Dent Res. 2023;102:759–66.
Google Scholar
Braga MM, Oliveira LB, Bonini GA, Bonecker M, Mendes FM. Feasibility of the international caries detection and assessment system (ICDAS-II) in epidemiological surveys and comparability with standard World Health Organization criteria. Caries Res. 2009;43:245–9.
Google Scholar
van der Tas JT, Kragt L, Veerkamp JJ, Jaddoe VW, Moll HA, Ongkosuwito EM, et al. Ethnic disparities in dental caries among six-year-old children in the Netherlands. Caries Res. 2016;50:489–97.
Google Scholar
Fan C, Guo L, Gu H, Huo Y, Lin H. Alterations in oral-nasal-pharyngeal microbiota and salivary proteins in mouth-breathing children. Front Microbiol. 2020;11:575550.
Google Scholar
Choi JE, Waddell JN, Lyons KM, Kieser JA. Intraoral pH and temperature during sleep with and without mouth breathing. J Oral Rehabil. 2016;43:356–63.
Google Scholar
Cattaneo C, Riso P, Laureati M, Gargari G, Pagliarini E. Exploring associations between interindividual differences in taste perception, oral microbiota composition, and reported food intake. Nutrients. 2019;11:1167.
Google Scholar
Mameli C, Cattaneo C, Panelli S, Comandatore F, Sangiorgio A, Bedogni G, et al. Taste perception and oral microbiota are associated with obesity in children and adolescents. PLoS One. 2019;14:e0221656.
Google Scholar
de Jesus VC, Mittermuller BA, Hu P, Schroth RJ, Chelikani P. Genetic variants in taste genes play a role in oral microbial composition and severe early childhood caries. iScience. 2022;25:105489.
Google Scholar
Riccio MP, Franco C, Negri R, Ferrentino RI, Maresca R, D’Alterio E, et al. Is food refusal in autistic children related to TAS2R38 genotype?. Autism Res. 2018;11:531–8.
Google Scholar
Ekman P FW, Hager J. Facial action coding system. Salt Lake City: Utah: Research Nexus, 2002.
link
